3Daughters Innovation

We are focused on Women’s Health innovation which is
desperately needed, and we are doing something about it.

Simple, Smart and Sophisticated

With a uniquely designed 3Daughters inserter (i-Glider™), each of the three magnetic units is inserted individually into the uterus and immediately self-assembles into a triangular ‘ring’ shape to adapt the lower energy triad conformation. This singularly unique configuration minimizes the magnetic energy of the system, achieving a complete “circuit” of magnetic flux closure. The 3 elliptical units of the 3Daughters IUD are easily removed from the uterus by using a uniquely designed retriever (r-Glider™) with a simple magnetic tip to attract the elliptical units individually into the r-Glider and withdraw from the uterus.  The sleeker and more patient-friendly design of the 3Daughters i-Glider and r-Glider (introducer and retriever) will add to an improved and less painful experience of our ergonomic IUD. The 3Daughters IUD is simple, smart, sophisticated, and based on physics and geometry. This unique frameless nonhormonal IUD is designed to conform to a woman’s body and improve upon the outdated T-shape frame to address the significant insertion pain and ‘fear factor’ that prevents many women from getting one of the most effective forms of birth control. The three small elliptical magnetic shapes of our IUD are inserted individually and self-assembled into a stable triangle that floats gently in the uterus. Our Glider™ for insertion (i-Glider) is far less painful and a simple magnetic retriever (r-Glider) completes the cycle – no strings needed.

Dr. Carlos Gradil, a world renown veterinary reproductive specialist, designed this frameless magnetic intrauterine device for horses. He understood the need for birth control, especially for performance horses in competitions. Like the early Middle East traders inserting pebbles into their camels, for years glass marbles were placed in the uterus of mares for just that purpose. However, in some cases the glass ball was spontaneously expelled, and many mares did not conceive subsequent to the glass ball removal. Complications were also reported including glass shards adhering to the endometrium.

Dr. Carlos Gradil, 3Daughters Inventor , Veterinary reproductive specialist, iUPOD, frameless magnetic intrauterine device, frameless IUD, IUD Pain Insertion

Dr. Carlos Gradil, a world renown veterinary reproductive specialist, designed a frameless magnetic intrauterine device for horses. He understood the need for birth control, especially for performance horses. Like the early Middle East traders inserting pebbles into their camels, for years glass marbles were placed in the uterus of mares for just that purpose. However, in some cases the glass ball was spontaneously expelled, and many mares did not conceive subsequent to the glass ball removal. Complications were also reported including glass shards adhering to the endometrium.

Dr. Carlos Gradil, 3Daughters Inventor , Veterinary reproductive specialist, iUPOD, frameless magnetic intrauterine device, frameless IUD, IUD Pain Insertion

Dr. Gradil devised the initial frameless magnetic IUD sized for horses as a self-assembling intrauterine device (iUpod) consisting of three elliptically shaped units each with a magnetic core. He demonstrated that the iUpod when inserted into mares prevented pregnancy, was retained in the uterus, with normal pre/post endometrial architecture, and 100% of the mares bred successfully in the following season. He has published his results in peer-reviewed publications including: Animal Reproductive Science and Journal of Equine Veterinary Science.

With this data in hand along with the established effectiveness of copper as a spermicide, 3Daughters approached the FDA with a refined design optimized for a woman’s anatomy and received feedback on our clinical development program. We are now preparing an IND (Investigational New Drug Application) to file with the FDA and begin our clinical testing in women.

We are just beginning to develop the potential of our unique technology and will be exploring other conditions, such as fibroids and abnormal bleeding, that could benefit from targeted therapy to the uterus.

Delivery

The 3Daughters technology of three elliptically shaped magnetic units coated with active pharmaceutical agents to the uterus provides an opportunity to deliver copper, a proven spermicide, to the uterus for contraception. The outdated T-shape frame has to be inserted to the top of the uterus (fundus) for accurate placement between the fallopian tubes. Anything touching the top of the fundus is a significant pain point for patients. 

The 3Daughters self-assembling stable triangular shape only needs to be inserted past the cervix into the middle of the uterus. This more flexible (forgiving) placement eliminates the need for ‘sounding’ which is used to measure the length of the uterus for accurate placement of the T-shape frame. The sound is a rigid instrument that is placed inside the uterus to directly measure the uterine cavity length. Once again, touching the top of the uterus represents pain points for patients.

With the 3Daughters magnetic elliptical system, at least two pain points will be eliminated during the IUD insertion procedure. Our advanced Glider for insertion has been developed for a woman’s anatomy with unique design elements providing superior flexibility compared to inserters/applicators currently on the market. This will also pave the way for the 3Daughters delivery system to treat other conditions occurring in the uterus, including fibroids and abnormal uterine bleeding.

3Daughters self-assembling IUD, Revolutionary IUD, Evolutionary IUD, Easy IUD insertion, No strings IUD, frameless, magnetic nonhormonal intrauterine device, best IUD, removing IUD, IUD side effects
T-shaped IUD, #painful, #IUD, IUD insertion, IUD strings, IUD in uterus